Is there any special setting anyone recommends? I'm not sure if this is from settings or the mod itself. Like I said, I did things far more strenuous, especially during the SS1 days. I think it might have something to do with multiple plots being built at once, but it shouldn't be that hard on the game. As far as progress, I am at the quest after you save Preston Garvy's group in Concord and the Stranger wants you to build an Agriculture and Industrial plot. I built up sanctuary to be much bigger on my old Desktop running only a GTX 1070. I'm running a Desktop with a Ryzon 9 12-Core, 32gb of RAM and a RTX 2080.
This is far less complicated than previous builds I have done. I have already built up sanctuary, but I kept my build small.